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National
72 major genetic risk factors for breast cancer identified in new study  
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72 major genetic risk factors for breast cancer identified in new study  

72 major genetic risk factors for breast cancer identified in new study  
Photo Credit: Raymond Boyd/Getty Images
A breast cancer awareness flag, flies outside the Borg Warner Building in Chicago in 2013.

72 major genetic risk factors for breast cancer identified in new study  

Two new studies published Monday in the journals Nature and Nature Genetics revealed 72 previously unknown genetic risk factors — or gene mutations — that lead to the development of breast cancer.

>> Read more trending news

The studies encompass work from more than 500 researchers at 300 institutions around the world, a collaboration headed by the OncoArray Consortium, a global network of scientists studying genomics.

The researchers examined genetic data, including blood samples, from a combined 275,000 women, 146,000 of whom had been diagnosed with breast cancer.

The bulk of the mutations found (65) predispose to the most common type of breast cancer, hormone receptor-positive (or ER-positive) breast cancer.

The other seven predispose to hormone receptor-negative breast cancer.

>> Related: Could dark hair dyes and chemical relaxers be linked to higher risk for breast cancer?

“These findings add significantly to our understanding of the inherited basis of breast cancer as well as identifying new genetic variants, we have also confirmed many that we had previously suspected,” study investigator Doug Easton of the University of Cambridge said. “There are some clear patterns in the genetic variants that should help us understand why some women are predisposed to breast cancer, and which genes and mechanisms are involved.”

How much can the newly identified genes predict about breast cancer risk?

Hormone receptor-positive breast cancer

There is sufficient scientific evidence to prove first-degree relatives of a hormone receptor-positive breast cancer patient have double the risk of getting breast cancer themselves compared to women without a family history of the cancer. 

>> Related: Why are more black women dying of breast cancer compared to white women?

After studying 122,977 cases of ER-positive cases, researchers can explain an additional 4 percent of that heritable breast cancer risk.

Previous research about the presence of common BRCA1 and BRCA 2 gene mutations show they also account for about 17 percent of heritable breast cancer risk.

With what the medical community already knows about BRCA1, BRCA2, other variants, plus the newly identified genes, it’s estimated that about 39 percent of heritable ER-positive breast cancer risk can be explained, researchers said.

Hormone receptor-negative breast cancer

>> Related: FDA approves Lilly pill for common advanced breast cancer

While studying 21,468 ER-negative cases, the researchers identified 10 new gene mutations that could explain approximately 1.5 of the heritable risk of ER-negative breast cancer. With the new research and previous research, the researchers can now explain 14 percent of the heritable risk.

“If you can differentiate women into groups of sufficiently different risks, you might be able to save more lives,” Roger Mine, lead researcher of the “Nature Genetics” study and co-author of the “Nature” study, said. One example: Women with different risks could receive tailored screenings. 

Read the full ER-negative study in Nature Genetics.

The researchers encourage clinicians to apply the new findings at the clinical level, but also urge future researchers to further study the mechanisms of the newly-identified gene mutations to learn more about how cancer manifests itself and how it can be better detected.

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Georgia Sports News

  • PHILADELPHIA (AP) - Nick Pivetta struck out seven over seven innings, and Nick Williams and Aaron Altherr each homered to lead the Phillies to a 3-0 win over the Atlanta Braves on Monday night. The Phillies took the opener of the three-game series and moved a half game behind Atlanta for first place in the NL East. Philadelphia hasn't had a winning record since it made the last of five straight postseason berths in 2011. The Phillies lost 96 games in 2017 - the third straight season of more than 90 losses. Under first-year manager Gabe Kapler, the Phillies are back in a battle for first in late May for the first time since Ryan Howard, Chase Utley and Cole Hamels dominated during the glory years. But in a year where the Eagles won the Super Bowl, Villanova won a national championship and the 76ers won 52 games, perhaps Philly fans need more than 45 games to hop on the bandwagon. Citizens Bank Park - the site of an NL-record 257 straight sellouts that ended in 2012 - was thin with just over 21,000 fans announced on a gorgeous night. 'It's a big one for us,' Kapler said. And, it came against a familiar rival. The Braves played the Phillies for a whopping 10th time already, resulting in this quirk: Atlanta starter Mike Foltynewicz faced Pivetta for the fourth time this season. Hard to believe, Harry. The right-handers each delivered outings worthy of two teams fighting for first. Pivetta (4-2) allowed only four hits, walked one and won his third straight start. Seranthony Dominguez tossed a scoreless eighth and Hector Neris finished the five-hitter in the ninth with his ninth save. Foltynewicz (3-3) allowed six hits and struck out five in six innings. His lone run allowed came when Williams hit a solo shot in the fourth, an opposite-field poke to left for his third homer of the year. The Phillies have homered in 16 straight games. Altherr pinch hit for Pivetta in the seventh and crushed a two-run homer to left off Shane Carle for a 3-0 lead. Two swings, one nice win. 'I take pride in the way a lot of our players have played,' Kapler said. 'I take pride in the way they've worked. I take pride in their preparation. I really love our players. I love coming to work with them every day. I ride the emotion that they ride.' The Phillies and Braves don't play again after this series until they face each other seven of the final 10 games of the season. Maybe in September, they'll be playing for the title. PHILLY SPECIAL Phillies LF Rhys Hoskins gave Doug Pederson some tips before the Eagles coach took some batting practice. Pederson, enjoying the perks of winning the Super Bowl, had already thrown out the first pitch at the home opener. He won a hitting contest against some Eagles rookies before the game and earned a Louisville Slugger bat inscribed with the title, '2018 Philadelphia Eagles batting champion.' TRAINER'S ROOM Braves: RHP Anibal Sanchez (hamstring) made a rehab start for Triple-A Gwinnett on Monday night. Phillies: SS J.P. Crawford (right elbow strain) fielded grounder at extended spring training. ... RHP Pat Neshek made 30 throws from flat ground as he recovers from a strained right shoulder. ... RHP Jared Eickhoff's return from a back injury suffered a setback when he felt a twinge in his right index and middle fingers during a rehab start. 'I don't think we're at the stage of deciding the level of concern. I think we're at the stage of evaluating,' Kapler said. UP NEXT Braves: RHP Brandon McCarthy (4-2, 5.05 ERA) looks to improve already to 4-0 this season against the Phillies. McCarthy has a 2.25 ERA in three starts that span just 16 innings. Phillies: RHP Vince Velasquez (4-4, 4.37) is already 0-3 against the Braves this season. Velasquez has lasted just 12 2-3 innings in three starts this season and is 0-4 lifetime against the Braves. ___ More AP baseball: https://apnews.com/tag/MLBbaseball
  • COLUMBUS — These Bulldog Club meetings — or Coaches’ Caravans, as they’re calling them this year — just aren’t that big of a deal anymore. That’s the only conclusion one can draw from the latest one, held Monday night at the Columbus Trade & Convention Center. Beautiful venue, by the way. Cool place. The Iron Works, I think they call this particular area, which features a lot of railroad tracks and reclaimed warehouses and the like. Georgia football coach Kirby Smart, men’s basketball coach Tom Crean and radio play-by-play personality Scott Howard flew down here Monday on UGA’s plane and then flew right back out after a short appearance in front of a smattering of fans and alumni. It wasn’t a bad crowd — about 290 according to one of the organizers — but they sort of got swallowed up by the expansive venue and a goodly portion of empty chairs. And based on the dozens and dozens of untouched crabcakes and chocolate-covered strawberries, they were expecting a lot more. But nobody was complaining. Well, there was that one guy at the back of the room. After Smart wrapped up his economical 10-minute speech — which remarkably included zero information about the actual football players — one man turned to his buddy next to him and said loud enough for everyone to hear, “he owes us another 25 minutes, doesn’t he?” Everybody laughed. Otherwise, though, it was what you usually expect of these annual events, especially coming off a 13-2 season and National Championship Game appearance. Smart — and Crean before him — was definitely feeling the love of the crowd. Smart received a rousing standing ovation, complete with barks and a lot of “woos” and “hoos.” Then he made them laugh. “After listening to Coach Crean, he had us all ready to bust through a brick wall,” Smart said. “But I decided I’d just bust through the curtains they have here.” Smart proceeded to tell the group how glad he was to be here in Columbus, which happens to be one of his favorite places. He also remarked about the “fertile recruiting ground” that the area is and thanked the fan base, again, for following the Bulldogs around the country during the magical 13-2 run last season. Then he basically ran through the schedule, where the Bulldogs are on the calendar, how hard the players are going to be worked this summer and the importance of the team concept. You know, “Together Everyone, Achieves More.” He hit on that for a while. Without going into specifics, Smart also mentioned that he has some depth concerns but added he is excited about the freshmen coming in next week and the prospects his staff is currently recruiting. Otherwise, there was no question-and-answer session, usually customary at these types of events. No, Smart addressed the pressing team matters in a 10-minute session with reporters beforehand. However, he and Crean did sign autographs and pose for pictures with fans before delivering their speeches, so perhaps fans got their pressing questions answered then. Sort of abruptly, Smart said thanks for coming and left. It was over. Howard came back to the podium just to make sure everybody knew. “That’s all we’ve got, folks,” he said with a wave of arms over his head, like he was stopping a play clock. “Thanks for coming. And go Dogs!” And off the Dogs went, back on their big bird to Athens. Of course, meetings such as these aren’t as necessary as they once were. Back when Dan Magill first made the UGA’s Bulldog Club tour the greatest of its kind in the country, it was a spectacle. It was a way to reach into the far corners of the state where perhaps Georgia’s coaches and overall presence wasn’t as readily accessible. Nowadays, people can access the Bulldogs anytime they want. There is no shortage of avenues, thanks to the World Wide Web, conference television networks and smart phones. Did I mention DawgNation’s app? But there is still something special about fans being somewhere live and in person with their heroes. Smart and Crean will take their mini tour next to Savannah, where they’ll likely follow a similar script Tuesday night. Then we won’t see them again in a public venue until late in the summer in Atlanta. There will be some donor stops between now and then, but nothing that welcomes “Everyman Fan” and a little media coverage. At the rate these events are regressing, this time next year we may only catch Kirby via hologram. The post Georgia’s Kirby Smart, Tom Crean face fewer dogs, still bring out barks in Columbus appeared first on DawgNation.
  • COLUMBUS — After returning home to Blackshear to discuss his options with his family and meeting for a second time with Georgia coach Kirby Smart, Stetson Bennett has decided … That he hasn’t yet decided where he wants to spend the rest of his football career. Bennett, a redshirt freshman who walked on from Pierce County, has been contemplating a transfer since the end of spring practice.The 6-foot, 172-pounder did not play for the Bulldogs last season but earned praise from coaches and teammates for his exceptional performances leading the scout-team offense against Georgia’s defense in practices. Bennett entered and exited Georgia’s spring drills as the No. 3 quarterback behind incumbent starter Jake Fromm and freshman early-enrollee Justin Fields. Bennett took snaps with both the Red and Black squads in the G-Day Game. He finished with 63 yards on 5-of-9 passing. Bennett has proven to be far from your average third-string quarterback. Defensive coordinator Mel Tucker called him “a beast” for his ability to escape pressure and throw the ball out of the pocket. Lorenzo Carter said Bennett made his “look silly” in Rose Bowl practices as they prepared for Oklahoma’s Baker Mayfield. Still, Bennett left Pierce County without any major college offers. His best were Middle Tennessee and Georgia Southern. But an exceptional student, he chose to walkon at UGA, where both his parents attended school. The post Kirby Smart making a hard play to keep QB Stetson Bennett at UGA appeared first on DawgNation.
  • Georgia baseball’s impressive regular season has garnered the attention of the rest of the SEC. Four Bulldogs have been named to the conference’s All-SEC teams announced Monday, one day before the SEC Tournament begins in Hoover, Ala. Leading the accolades for Georgia is senior left fielder Keegan McGovern. Not only was McGovern an All-SEC first team selection, but also he was named the SEC’s Co-Scholar Athlete of the Year alongside Nico Mascia of Tennessee. Mascia holds a 3.99 GPA in biomolecular engineering. McGovern holds a 3.48 GPA in biology. Nico Mascia and @keeganmcgovern are the #SECBSB Co-Scholar Athletes of the Year! pic.twitter.com/8ow7dNXw2T — Southeastern Conference (@SEC) May 21, 2018 “McGovern holds a 3.48 grade point average in biology. He has been named to the SEC Academic Honor Roll in every semester and is a member of UGA’s Student-Athlete Leadership Academy, chosen based on academic, athletic success, leadership, and campus and community involvement,” according to the SEC release. McGovern leads the Bulldogs with a .330 batting average, .639 slugging percentage, 62 runs, and 15 home runs. While he was selected to the All-SEC first team, two of his teammates made the second team. First baseman Adam Sasser and DH Michael Curry both earned All-SEC second team honors. Also, freshman catcher Mason Meadows made the All-Freshman team. Georgia begins play in the SEC Tournament on Wednesday at 10:30 a.m. ET, when they will face the winner of Texas A&M and Vanderbilt from Tuesday. The Bulldogs can cement their case for a top-8 national seed with a deep run this week in Hoover. The post Georgia senior Keegan McGovern named SEC Scholar Athlete, leads 4 Bulldogs on All-SEC teams appeared first on DawgNation.
  • Let everyone know your Georgia Bulldogs are going for the win when you wear this cool and comfy Fanatics Branded tee. This Freedom tri-blend T-shirt has dynamic graphics that will easily proclaim your game day excitement. This special gear is an awesome way to watch the Georgia Bulldogs dominate their opponents. Details Material: 50% Cotton/37% Polyester/13% Rayon Screen print graphics Rib-knit collar Extremely soft, lightweight feel Crew neck Short sleeve Tagless Collar Officially licensed Imported Brand: Fanatics Branded $29.99 The post Georgia Bulldogs Freedom Tri-Blend T-Shirt appeared first on DawgNation.